ABSTRACT
Diabetes mellitus is a world-widely public health issue associated with premature mortality, decreased quality of life and increased health-care expenditures. The aim of the review was to elevate the effect of apple cider vinegar on glycemic control, hyperlipidemia and obesity control in type 2 diabetes patients. Many clinical trials showed the hypoglycemic, hypolipidemic and anti-obesity effect of vinegar. Proposed mechanisms action of vinegar for the hypoglycemic, hypolipidemic effect are including slow gastric emptying, it promotes uptake of skeleton muscles glucose in the body and acetic acid may inhibit disaccharides activity in the small intestine blocking the complete digestion of starch molecules, suppression of hepatic glucose production and increased glucose utilization. Results of previous studies showed that apple cider vinegar has the potential of anti-diabetic, antihyperlipidemic and antiobesity effects in diabetes mellitus patients. Objective of review: The objective of the current review study was to investigate the effect of apple cider vinegar on glycemic control, hyperlipidemia and control on body weight in type 2 diabetes patients and other therapeutic and commercial effect of apple cider vinegar. Data sources: To collect data for relevant literature PubMed, Google Scholar, science direct and Cochrane sources were used.
ABSTRACT
Aim: The aim of the trial was to measure the effect of apple cider vinegar on glycemic control and biochemical parameters in type 2 diabetes mellitus (DM) patients with poor glycemic control. Methods: A single-blind, randomized, placebo-controlled trial was conducted on 110 eligible types 2 DM patients who were selected and allocated into 2 groups. The interventional group was given 15 ml apple cider vinegar in 200 ml water during dinner for 3 months while the other group was placebo. Before and after HbA1C (glycosylated hemoglobin), fasting lipid profile, fasting blood sugar, anthropometrics, and dietary changes were assessed and analyzed using IBM SPSS version 20, through statistical tests. Formal ethical approval was obtained from the local institutional review board. Results: Significant mean change was found in interventional group in HbA1c (p<0.001), blood sugar fasting (p<0.001), total cholesterol (p=0.002), triglyceride (p=0.002) and hip-waist ratio (p=0.002). No significant change was observed in the mean of these statistics in the placebo group. No significant change was observed in height, weight, mid-upper arm ratio, and low density lipoprotein, high density lipoprotein and food frequency in intervention and placebo groups before and after. Conclusion: Apple cider vinegar if used regularly is effective in controlling diabetes, lowering hypercholesterolemia and hypertriglyceridemia in DM type 2 patients.
ABSTRACT
Introduction: The most common childhood orbital malignancy is the rhabdomyosarcoma contributing almost 10% of all RMS cases. The mean age of orbital RMS is 6-8 years and rare case of RMS from birth to the 8th decade was reported. Male are more affected as compared to female. Total 60.4% male were affected with RMS as compared to female was 39.6%. Objective: The objective of the current study was to describe a case of recurrent orbital rhabdomyosarcoma and effectiveness of chemotherapy to RMS in a 2 year old child. Methods: Computer tomography, magnetic resonance images and excision biopsy were done for confirmation of tumor. After confirmation patient was treated with chemotherapy. Results: Excision biopsy showed tumor composed of round blue cells with high nodular cells ratio and hyper chromatic nuclei and finding also presented favors of Embreyonal rhabdomyosarcoma and child was treated with chemotherapy after completion of chemotherapy course this little child was came to his normal life but after 6 months sudden symptoms of recurrence has been appeared and this time tumor was most aggressive and cannot be controlled with only chemotherapy treatment. Conclusion: To achieve a good survival rate of RMS in children and elderly age there is a need to complete surgical tumor resection in anywhere of the body. Only chemotherapy should not be helpful and cannot be preventable from recurrence. Early diagnosis and stared treatment is the best approach and any delay in diagnosis can have a negative effect on health status.